Structural analysis of an HIV-1 protease I47A mutant resistant to the protease inhibitor lopinavir.

Kagan, Ron M; Shenderovich, Mark D; Heseltine, Peter N R; Ramnarayan, Kal

Kagan, Ron M; Shenderovich, Mark D; Heseltine, Peter N R; Ramnarayan, Kal.

Affiliation

Kagan RM; Department of Infectious Diseases, Quest Diagnostics Inc., San Juan Capistrano, CA 92675, USA. kaganr@questdiagnostics.com

Protein Sci ; 14(7): 1870-8, 2005 Jul.

Article in En | MEDLINE | ID: mdl-15937277

Subject(s)

Drug Resistance, Viral/genetics; HIV Protease Inhibitors/pharmacology; HIV Protease/chemistry; HIV-1/enzymology; Mutation/genetics; Pyrimidinones/pharmacology; Genotype; HIV Protease/genetics; HIV Protease/metabolism; HIV Protease Inhibitors/chemistry; HIV-1/drug effects; HIV-1/genetics; Humans; Kinetics; Lopinavir; Models, Molecular; Molecular Structure; Phenotype; Protein Binding; Protein Conformation; Pyrimidinones/chemistry; Saquinavir/chemistry; Saquinavir/pharmacology; Saquinavir/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidinones / HIV Protease / HIV-1 / HIV Protease Inhibitors / Drug Resistance, Viral / Mutation Limits: Humans Language: En Journal: Protein Sci Journal subject: BIOQUIMICA Year: 2005 Type: Article Affiliation country: United States

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