Endogenous gamma-aminobutyric acid (GABA)(A) receptor active neurosteroids and the sedative/hypnotic action of gamma-hydroxybutyric acid (GHB): a study in GHB-S (sensitive) and GHB-R (resistant) rat lines.

Barbaccia, Maria Luisa; Carai, Mauro A M; Colombo, Giancarlo; Lobina, Carla; Purdy, Robert H; Gessa, Gian Luigi

Barbaccia, Maria Luisa; Carai, Mauro A M; Colombo, Giancarlo; Lobina, Carla; Purdy, Robert H; Gessa, Gian Luigi.

Affiliation

Barbaccia ML; Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy. barbaccia@med.uniroma2.it

Neuropharmacology ; 49(1): 48-58, 2005 Jul.

Article in En | MEDLINE | ID: mdl-15992580

Subject(s)

Brain/drug effects; Hydroxybutyrates/pharmacology; Hypnotics and Sedatives/pharmacology; Pregnanes/metabolism; Receptors, GABA-A/physiology; Reflex/drug effects; Analysis of Variance; Animals; Brain/metabolism; Brain Chemistry/drug effects; Dose-Response Relationship, Drug; Female; Male; Pregnanes/classification; Radioimmunoassay/methods; Rats; Reaction Time/drug effects; Reaction Time/physiology; Receptors, GABA-A/drug effects; Reflex/physiology; Sex Factors; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Pregnanes / Reflex / Brain / Receptors, GABA-A / Hydroxybutyrates / Hypnotics and Sedatives Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Neuropharmacology Year: 2005 Type: Article Affiliation country: Italy

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