N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells.

Bahlis, Nizar J; Miao, Yanling; Koc, Omer N; Lee, Kelvin; Boise, Lawrence H; Gerson, Stanton L

Bahlis, Nizar J; Miao, Yanling; Koc, Omer N; Lee, Kelvin; Boise, Lawrence H; Gerson, Stanton L.

Affiliation

Bahlis NJ; University of Calgary, Department of Medicine, Division of Hematology and Hematological Malignancies, Calgary, Alberta, Canada.

Leuk Lymphoma ; 46(6): 899-908, 2005 Jun.

Article in En | MEDLINE | ID: mdl-16019536

Subject(s)

Apoptosis; Enzyme Inhibitors/pharmacology; Multiple Myeloma/drug therapy; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Staurosporine/analogs & derivatives; Amino Acid Chloromethyl Ketones/pharmacology; Caspase 3/metabolism; Cell Line, Tumor; Flow Cytometry/methods; Humans; Interleukin-6/metabolism; Membrane Potentials; Mitochondria/metabolism; Multiple Myeloma/metabolism; Phosphorylation; Staurosporine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Staurosporine / Enzyme Inhibitors / Proto-Oncogene Proteins c-akt / Multiple Myeloma Type of study: Guideline Limits: Humans Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2005 Type: Article Affiliation country: Canada

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