Trapidil enhances the slowly activating delayed rectifier potassium current and suppresses the transient inward current induced by catecholamine in Guinea pig ventricular myocytes.

Marumoto, Akira; Hasegawa, Junichi; Zhang, Fang; Moritani, Hisato; Harada, Tomomi; Sano, Akiko; Miura, Norimasa; Kishimoto, Yosuke; Ohgi, Shigetsugu

Marumoto, Akira; Hasegawa, Junichi; Zhang, Fang; Moritani, Hisato; Harada, Tomomi; Sano, Akiko; Miura, Norimasa; Kishimoto, Yosuke; Ohgi, Shigetsugu.

Affiliation

Marumoto A; Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, Yonago, Japan.

J Cardiovasc Pharmacol ; 46(2): 167-76, 2005 Aug.

Article in En | MEDLINE | ID: mdl-16044028

Subject(s)

Action Potentials/drug effects; Heart Ventricles/cytology; Myocytes, Cardiac/drug effects; Potassium Channels, Inwardly Rectifying/metabolism; Potassium/metabolism; Trapidil/pharmacology; Adrenergic beta-Agonists/pharmacology; Animals; Calcium Channels, L-Type/metabolism; Catecholamines/pharmacology; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isoproterenol/pharmacology; Male; Microelectrodes; Myocytes, Cardiac/physiology; Patch-Clamp Techniques; Ryanodine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Potassium / Trapidil / Action Potentials / Potassium Channels, Inwardly Rectifying / Myocytes, Cardiac / Heart Ventricles Limits: Animals Language: En Journal: J Cardiovasc Pharmacol Year: 2005 Type: Article Affiliation country: Japan

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