Liposome-DNA complexes infused intravenously inhibit tumor angiogenesis and elicit antitumor activity in dogs with soft tissue sarcoma.

Kamstock, D; Guth, A; Elmslie, R; Kurzman, I; Liggitt, D; Coro, L; Fairman, J; Dow, S

Kamstock, D; Guth, A; Elmslie, R; Kurzman, I; Liggitt, D; Coro, L; Fairman, J; Dow, S.

Affiliation

Kamstock D; Department of Microbiology, Immunology, and Pathology, Colorado State University, Ft Collins, 80523, USA.

Cancer Gene Ther ; 13(3): 306-17, 2006 Mar.

Article in En | MEDLINE | ID: mdl-16138118

Subject(s)

DNA/administration & dosage; Dog Diseases/prevention & control; Endostatins/genetics; Neovascularization, Pathologic/veterinary; Sarcoma/veterinary; Skin Neoplasms/veterinary; Animals; Dog Diseases/metabolism; Dogs; Endothelium, Vascular/metabolism; Endothelium, Vascular/pathology; Fibrosarcoma/blood supply; Fibrosarcoma/therapy; Fibrosarcoma/veterinary; Genetic Vectors; Infusions, Intravenous; Liposomes/administration & dosage; Luciferases/genetics; Luciferases/metabolism; Mice; Neovascularization, Pathologic/metabolism; Sarcoma/blood supply; Sarcoma/metabolism; Skin Neoplasms/blood supply; Skin Neoplasms/metabolism; Spleen/metabolism; Spleen/pathology; Transgenes/physiology; Vascular Endothelial Growth Factor A/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma / Skin Neoplasms / DNA / Endostatins / Dog Diseases / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cancer Gene Ther Journal subject: GENETICA MEDICA / NEOPLASIAS / TERAPEUTICA Year: 2006 Type: Article Affiliation country: United States

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