Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.

Maehr, René; Mintern, Justine D; Herman, Ann E; Lennon-Duménil, Ana-Maria; Mathis, Diane; Benoist, Christophe; Ploegh, Hidde L

Maehr, René; Mintern, Justine D; Herman, Ann E; Lennon-Duménil, Ana-Maria; Mathis, Diane; Benoist, Christophe; Ploegh, Hidde L.

Affiliation

Maehr R; Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

J Clin Invest ; 115(10): 2934-43, 2005 Oct.

Article in En | MEDLINE | ID: mdl-16184198

Subject(s)

CD4-Positive T-Lymphocytes/immunology; Cathepsins/immunology; Cysteine Endopeptidases/immunology; Diabetes Mellitus, Experimental/immunology; Diabetes Mellitus, Type 1/immunology; Histocompatibility Antigens Class II/immunology; T-Lymphocyte Subsets/immunology; Animals; CD4-Positive T-Lymphocytes/pathology; Cathepsin L; Cathepsins/genetics; Cysteine Endopeptidases/genetics; Diabetes Mellitus, Experimental/genetics; Diabetes Mellitus, Experimental/pathology; Diabetes Mellitus, Type 1/genetics; Diabetes Mellitus, Type 1/pathology; Lysosomes/immunology; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Knockout; Pancreas/immunology; Pancreas/pathology; T-Lymphocyte Subsets/pathology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine Endopeptidases / CD4-Positive T-Lymphocytes / Histocompatibility Antigens Class II / Cathepsins / T-Lymphocyte Subsets / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 1 Limits: Animals Language: En Journal: J Clin Invest Year: 2005 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google