Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.

Federici, Massimo; Hribal, Marta L; Menghini, Rossella; Kanno, Hiroko; Marchetti, Valentina; Porzio, Ottavia; Sunnarborg, Susan W; Rizza, Stefano; Serino, Matteo; Cunsolo, Veronica; Lauro, Davide; Mauriello, Alessandro; Smookler, David S; Sbraccia, Paolo; Sesti, Giorgio; Lee, David C; Khokha, Rama; Accili, Domenico; Lauro, Renato

Federici, Massimo; Hribal, Marta L; Menghini, Rossella; Kanno, Hiroko; Marchetti, Valentina; Porzio, Ottavia; Sunnarborg, Susan W; Rizza, Stefano; Serino, Matteo; Cunsolo, Veronica; Lauro, Davide; Mauriello, Alessandro; Smookler, David S; Sbraccia, Paolo; Sesti, Giorgio; Lee, David C; Khokha, Rama; Accili, Domenico; Lauro, Renato.

Affiliation

Federici M; Center for Atherosclerosis, Policlinico Tor Vergata University Hospital, Rome, Italy. federicm@uniroma2.it

J Clin Invest ; 115(12): 3494-505, 2005 Dec.

Article in En | MEDLINE | ID: mdl-16294222

Subject(s)

Inflammation/genetics; Receptor, Insulin/metabolism; Tissue Inhibitor of Metalloproteinase-3/genetics; Tissue Inhibitor of Metalloproteinase-3/physiology; Tumor Necrosis Factor-alpha/genetics; Analysis of Variance; Animals; Deoxyglucose/metabolism; Diabetes Mellitus/pathology; Electrophoresis, Polyacrylamide Gel; Gene Expression Profiling; Genetic Vectors; Glucose/metabolism; Glucose Tolerance Test; Glycogen/chemistry; Heterozygote; Homeostasis; Hyperglycemia/pathology; Hyperinsulinism/pathology; Insulin/metabolism; Liver/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal/pathology; Muscles/pathology; Phosphorylation; Promoter Regions, Genetic; Protein Binding; RNA/chemistry; RNA/metabolism; RNA, Messenger/metabolism; RNA, Small Interfering/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Tissue Inhibitor of Metalloproteinase-3/metabolism; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Insulin / Tumor Necrosis Factor-alpha / Tissue Inhibitor of Metalloproteinase-3 / Inflammation Type of study: Prognostic_studies Language: En Journal: J Clin Invest Year: 2005 Type: Article Affiliation country: Italy

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