Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers.

Yeh, Rosa F; Gaver, Vincent E; Patterson, Kristine B; Rezk, Naser L; Baxter-Meheux, Faustina; Blake, Michael J; Eron, Joseph J; Klein, Cheri E; Rublein, John C; Kashuba, Angela D M

Yeh, Rosa F; Gaver, Vincent E; Patterson, Kristine B; Rezk, Naser L; Baxter-Meheux, Faustina; Blake, Michael J; Eron, Joseph J; Klein, Cheri E; Rublein, John C; Kashuba, Angela D M.

Affiliation

Yeh RF; School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA.

J Acquir Immune Defic Syndr ; 42(1): 52-60, 2006 May.

Article in En | MEDLINE | ID: mdl-16639344

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; HIV Protease Inhibitors/administration & dosage; Intestines/enzymology; Liver/enzymology; Pyrimidinones/administration & dosage; Ritonavir/administration & dosage; Administration, Oral; Adolescent; Adult; Aryl Hydrocarbon Hydroxylases/biosynthesis; Biomarkers/urine; Caffeine/administration & dosage; Caffeine/pharmacokinetics; Cytochrome P-450 CYP1A2/biosynthesis; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A/metabolism; Drug Therapy, Combination; Enzyme Induction; Female; HIV Seronegativity; Humans; Injections, Intravenous; Intestinal Mucosa/metabolism; Liver/metabolism; Lopinavir; Male; Midazolam/administration & dosage; Midazolam/pharmacokinetics; Middle Aged; Mixed Function Oxygenases/biosynthesis; Omeprazole/administration & dosage; Omeprazole/pharmacokinetics; Substrate Specificity; Warfarin/administration & dosage; Warfarin/pharmacokinetics

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidinones / HIV Protease Inhibitors / Ritonavir / Cytochrome P-450 Enzyme System / Intestines / Liver Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: J Acquir Immune Defic Syndr Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2006 Type: Article Affiliation country: United States

Search on Google

XML

PubMed Links