Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors.

Watson, Nigel S; Brown, David; Campbell, Matthew; Chan, Chuen; Chaudry, Laiq; Convery, Máire A; Fenwick, Rebecca; Hamblin, J Nicole; Haslam, Claudine; Kelly, Henry A; King, N Paul; Kurtis, Cynthia L; Leach, Andrew R; Manchee, Gary R; Mason, Andrew M; Mitchell, Charlotte; Patel, Champa; Patel, Vipulkumar K; Senger, Stefan; Shah, Gita P; Weston, Helen E; Whitworth, Caroline; Young, Robert J

Watson, Nigel S; Brown, David; Campbell, Matthew; Chan, Chuen; Chaudry, Laiq; Convery, Máire A; Fenwick, Rebecca; Hamblin, J Nicole; Haslam, Claudine; Kelly, Henry A; King, N Paul; Kurtis, Cynthia L; Leach, Andrew R; Manchee, Gary R; Mason, Andrew M; Mitchell, Charlotte; Patel, Champa; Patel, Vipulkumar K; Senger, Stefan; Shah, Gita P; Weston, Helen E; Whitworth, Caroline; Young, Robert J.

Affiliation

Watson NS; GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK. Nigel.S.Watson@gsk.com

Bioorg Med Chem Lett ; 16(14): 3784-8, 2006 Jul 15.

Article in En | MEDLINE | ID: mdl-16697194

Subject(s)

Antithrombin III/pharmacology; Fibrinolytic Agents/pharmacology; Pyrrolidinones/pharmacology; Thrombin/drug effects; Administration, Oral; Animals; Antithrombin III/chemical synthesis; Biological Availability; Fibrinolytic Agents/chemical synthesis; Male; Pyrrolidinones/chemical synthesis; Rats; Rats, Wistar

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidinones / Thrombin / Antithrombin III / Fibrinolytic Agents Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Type: Article Affiliation country: United kingdom

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