Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways.

Grimm, Dirk; Streetz, Konrad L; Jopling, Catherine L; Storm, Theresa A; Pandey, Kusum; Davis, Corrine R; Marion, Patricia; Salazar, Felix; Kay, Mark A

Grimm, Dirk; Streetz, Konrad L; Jopling, Catherine L; Storm, Theresa A; Pandey, Kusum; Davis, Corrine R; Marion, Patricia; Salazar, Felix; Kay, Mark A.

Affiliation

Grimm D; Stanford University, School of Medicine, Department of Pediatrics, Stanford, California 94305, USA.

Nature ; 441(7092): 537-41, 2006 May 25.

Article in En | MEDLINE | ID: mdl-16724069

Subject(s)

MicroRNAs/metabolism; MicroRNAs/toxicity; Nucleic Acid Conformation; RNA/metabolism; RNA/toxicity; Animals; Hepatitis B virus/physiology; Humans; Karyopherins/metabolism; Liver/drug effects; Liver/injuries; Liver/metabolism; Liver/pathology; Liver Regeneration; Mice; Mice, Transgenic; MicroRNAs/genetics; RNA/chemistry; RNA/genetics; RNA Interference; Survival Analysis

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Collection: 01-internacional Database: MEDLINE Main subject: RNA / MicroRNAs / Nucleic Acid Conformation Limits: Animals / Humans Language: En Journal: Nature Year: 2006 Type: Article Affiliation country: United States

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