Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation.

Sakurai, Toshiharu; Maeda, Shin; Chang, Lufen; Karin, Michael

Sakurai, Toshiharu; Maeda, Shin; Chang, Lufen; Karin, Michael.

Affiliation

Sakurai T; Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093-0723, USA.

Proc Natl Acad Sci U S A ; 103(28): 10544-51, 2006 Jul 11.

Article in En | MEDLINE | ID: mdl-16807293

Subject(s)

Carcinoma, Hepatocellular/chemically induced; Carcinoma, Hepatocellular/enzymology; Liver Neoplasms/chemically induced; Liver Neoplasms/enzymology; Mitogen-Activated Protein Kinase 8/metabolism; NF-kappa B/antagonists & inhibitors; NF-kappa B/metabolism; Alkylating Agents/toxicity; Animals; Carcinoma, Hepatocellular/pathology; Diethylnitrosamine/toxicity; Enzyme Activation/drug effects; Enzyme Activation/physiology; I-kappa B Kinase/deficiency; I-kappa B Kinase/genetics; Liver Neoplasms/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 8/deficiency; Mitogen-Activated Protein Kinase 8/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-kappa B / Carcinoma, Hepatocellular / Mitogen-Activated Protein Kinase 8 / Liver Neoplasms Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2006 Type: Article Affiliation country: United States

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