Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways.

Dasgupta, Piyali; Rastogi, Shipra; Pillai, Smitha; Ordonez-Ercan, Dalia; Morris, Mark; Haura, Eric; Chellappan, Srikumar

Dasgupta, Piyali; Rastogi, Shipra; Pillai, Smitha; Ordonez-Ercan, Dalia; Morris, Mark; Haura, Eric; Chellappan, Srikumar.

Affiliation

Dasgupta P; Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612, USA.

J Clin Invest ; 116(8): 2208-2217, 2006 Aug.

Article in En | MEDLINE | ID: mdl-16862215

Subject(s)

Arrestins/physiology; Cell Division/drug effects; Nicotine/pharmacology; Proto-Oncogene Proteins c-raf/metabolism; Retinoblastoma Protein/metabolism; src-Family Kinases/metabolism; Carcinoma, Non-Small-Cell Lung/pathology; Cell Line; Cell Line, Tumor; Enzyme Activation; Humans; Lung Neoplasms/pathology; Promoter Regions, Genetic; Receptors, Nicotinic/drug effects; Receptors, Nicotinic/physiology; Retinoblastoma Protein/antagonists & inhibitors; Retinoblastoma Protein/drug effects; beta-Arrestins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Division / Retinoblastoma Protein / Src-Family Kinases / Arrestins / Proto-Oncogene Proteins c-raf / Nicotine Limits: Humans Language: En Journal: J Clin Invest Year: 2006 Type: Article Affiliation country: United States

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