Full validation of an analytical method for the HIV-protease inhibitor atazanavir in combination with 8 other antiretroviral agents and its applicability to therapeutic drug monitoring.

Rezk, Naser L; Crutchley, Rustin D; Yeh, Rosa F; Kashuba, Angela D M

Rezk, Naser L; Crutchley, Rustin D; Yeh, Rosa F; Kashuba, Angela D M.

Affiliation

Rezk NL; Clinical Pharmacology/Analytical Chemistry Core, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. naser2@unc.edu

Ther Drug Monit ; 28(4): 517-25, 2006 Aug.

Article in En | MEDLINE | ID: mdl-16885719

Subject(s)

Chromatography, High Pressure Liquid/methods; Drug Monitoring/methods; HIV Protease Inhibitors/blood; Oligopeptides/blood; Pyridines/blood; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Calibration; Chromatography, High Pressure Liquid/standards; Drug Monitoring/economics; Drug Stability; HIV Protease Inhibitors/therapeutic use; Humans; Molecular Structure; Oligopeptides/chemistry; Oligopeptides/therapeutic use; Pyridines/chemistry; Pyridines/therapeutic use; Quality Control; Reference Standards; Reproducibility of Results; Solutions/analysis; Solutions/chemistry; Spectrophotometry, Ultraviolet/methods

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Pyridines / Chromatography, High Pressure Liquid / Drug Monitoring / HIV Protease Inhibitors Limits: Humans Language: En Journal: Ther Drug Monit Year: 2006 Type: Article Affiliation country: United States

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