Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts.

Nguyen, Quang-Dé; Rodrigues, Sylvie; Rodrigue, Christelle M; Rivat, Christine; Grijelmo, Clara; Bruyneel, Erik; Emami, Shahin; Attoub, Samir; Gespach, Christian

Nguyen, Quang-Dé; Rodrigues, Sylvie; Rodrigue, Christelle M; Rivat, Christine; Grijelmo, Clara; Bruyneel, Erik; Emami, Shahin; Attoub, Samir; Gespach, Christian.

Affiliation

Nguyen QD; Institut National de la Sante et de la Recherche Medicale U673, Université Pierre et Marie Curie-Paris 6, Molecular and Clinical Oncology of Solid Tumors, Hôpital Saint-Antoine, 75571 Paris Cedex 12, France.

Mol Cancer Ther ; 5(8): 2070-7, 2006 Aug.

Article in En | MEDLINE | ID: mdl-16928828

Subject(s)

Colonic Neoplasms/drug therapy; Quinazolines/pharmacology; Semaphorin-3A/metabolism; Triazoles/pharmacology; Vascular Endothelial Growth Factor A/antagonists & inhibitors; Animals; Cisplatin/pharmacology; Colonic Neoplasms/pathology; Enzyme Inhibitors/pharmacology; Female; Humans; Lung Neoplasms/drug therapy; Lung Neoplasms/pathology; Mice; Mice, Nude; Mitogen-Activated Protein Kinases/metabolism; Neoplasm Invasiveness; Piperidines/pharmacology; Receptors, Vascular Endothelial Growth Factor/drug effects; Receptors, Vascular Endothelial Growth Factor/metabolism; Semaphorin-3A/drug effects; Signal Transduction; Vascular Endothelial Growth Factor A/metabolism; Xenograft Model Antitumor Assays

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Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Triazoles / Colonic Neoplasms / Semaphorin-3A / Vascular Endothelial Growth Factor A Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2006 Type: Article Affiliation country: France

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