Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis.
J Exp Med
; 172(1): 367-70, 1990 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-1694224
ABSTRACT
Human protectin (CD59) is an 18-20-kD membrane glycoprotein that restricts lysis of human erythrocytes and leukocytes by homologous complement. By directly incorporating protectin into membranes of heterologous cells we observed that protectin did not prevent perforin-mediated killing, whereas complement killing was effectively restricted. Further, no significant enhancement of cell-mediated killing or target killing by purified perforin was observed with anti-protectin antibodies. Thus, in contrast with complement lysis, restriction of lysis by protectin does not apply to cell-mediated killing.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Complement System Proteins
/
Membrane Glycoproteins
/
Antigens, Differentiation
/
Antigens, CD
/
Hemolysis
/
Membrane Proteins
Limits:
Animals
/
Humans
Language:
En
Journal:
J Exp Med
Year:
1990
Type:
Article
Affiliation country:
United kingdom