Treatment of high risk medulloblastomas in children above the age of 3 years: a SFOP study.
Eur J Cancer
; 42(17): 3004-14, 2006 Nov.
Article
in En
| MEDLINE
| ID: mdl-16956759
ABSTRACT
AIM:
Improvement of EFS of children older than 3 years with high risk medulloblastoma.METHODS:
Between 1993 and 1999, 115 patients (3-18 years, mean 8 years) with high risk medulloblastoma were included. After surgery treatment consisted of chemotherapy ('8in1' and etoposide/carboplatin) before and after craniospinal radiotherapy.RESULTS:
Patients were staged using Chang-criteria (PF residue only, M1 and M2/M3) by local investigator as well as by central review panel (82.4% concordance). Chemotherapy was well tolerated without major delays in radiotherapy. With a mean follow up of 81 months (9-119), 5-year EFS was 49.8% and OS 60.1%. In detail according to subgroups EFS was 68.8% for PF residue only, 58.8% for M1 disease and 43.1% for M2/M3.CONCLUSION:
M1 patients are legitimate high risk patients. Survival rates are still very low for high risk medulloblastoma patients and future trials should therefore focus on more intensive (chemotherapy/radiotherapy) treatment.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antineoplastic Combined Chemotherapy Protocols
/
Cerebellar Neoplasms
/
Medulloblastoma
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Child, preschool
/
Humans
Language:
En
Journal:
Eur J Cancer
Year:
2006
Type:
Article
Affiliation country:
France