Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.

Lalioti, Maria D; Zhang, Junhui; Volkman, Heather M; Kahle, Kristopher T; Hoffmann, Kristin E; Toka, Hakan R; Nelson-Williams, Carol; Ellison, David H; Flavell, Richard; Booth, Carmen J; Lu, Yin; Geller, David S; Lifton, Richard P

Lalioti, Maria D; Zhang, Junhui; Volkman, Heather M; Kahle, Kristopher T; Hoffmann, Kristin E; Toka, Hakan R; Nelson-Williams, Carol; Ellison, David H; Flavell, Richard; Booth, Carmen J; Lu, Yin; Geller, David S; Lifton, Richard P.

Affiliation

Lalioti MD; Department of Genetics, Howard Hughes Medical, Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Nat Genet ; 38(10): 1124-32, 2006 Oct.

Article in En | MEDLINE | ID: mdl-16964266

Subject(s)

Blood Pressure/physiology; Kidney Tubules, Distal/metabolism; Potassium/metabolism; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Animals; Chromosomes, Artificial, Bacterial; Electrolytes/blood; Female; Homeostasis; Humans; Kidney Tubules, Distal/diagnostic imaging; Mice; Mice, Transgenic; Mutation; Pseudohypoaldosteronism/genetics; Sodium Chloride Symporters/genetics; Sodium Chloride Symporters/metabolism; Ultrasonography

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Collection: 01-internacional Database: MEDLINE Main subject: Potassium / Blood Pressure / Protein Serine-Threonine Kinases / Kidney Tubules, Distal Type of study: Diagnostic_studies Limits: Animals / Female / Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2006 Type: Article Affiliation country: United States

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