1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists.

McLean, Thomas H; Parrish, Jason C; Braden, Michael R; Marona-Lewicka, Danuta; Gallardo-Godoy, Alejandra; Nichols, David E

McLean, Thomas H; Parrish, Jason C; Braden, Michael R; Marona-Lewicka, Danuta; Gallardo-Godoy, Alejandra; Nichols, David E.

Affiliation

McLean TH; Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47907-1333, USA.

J Med Chem ; 49(19): 5794-803, 2006 Sep 21.

Article in En | MEDLINE | ID: mdl-16970404

Subject(s)

Bridged Bicyclo Compounds/chemical synthesis; Hallucinogens/chemical synthesis; Methylamines/chemical synthesis; Phenethylamines/chemical synthesis; Serotonin 5-HT2 Receptor Agonists; Animals; Arachidonic Acid/biosynthesis; Binding, Competitive; Bridged Bicyclo Compounds/chemistry; Bridged Bicyclo Compounds/pharmacology; Cells, Cultured; Crystallography, X-Ray; Discrimination Learning/drug effects; Hallucinogens/chemistry; Hallucinogens/pharmacology; Humans; Inositol Phosphates/biosynthesis; Ligands; Lysergic Acid Diethylamide/pharmacology; Male; Methylamines/chemistry; Methylamines/pharmacology; Models, Molecular; Molecular Conformation; Phenethylamines/chemistry; Phenethylamines/pharmacology; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Phenethylamines / Bridged Bicyclo Compounds / Serotonin 5-HT2 Receptor Agonists / Hallucinogens / Methylamines Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Type: Article Affiliation country: United States

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