Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance.

Agostini, Maura; Schoenmakers, Erik; Mitchell, Catherine; Szatmari, Istvan; Savage, David; Smith, Aaron; Rajanayagam, Odelia; Semple, Robert; Luan, Jian'an; Bath, Louise; Zalin, Anthony; Labib, Mourad; Kumar, Sudhesh; Simpson, Helen; Blom, Dirk; Marais, David; Schwabe, John; Barroso, Inês; Trembath, Richard; Wareham, Nicholas; Nagy, Laszlo; Gurnell, Mark; O'Rahilly, Stephen; Chatterjee, Krishna

Agostini, Maura; Schoenmakers, Erik; Mitchell, Catherine; Szatmari, Istvan; Savage, David; Smith, Aaron; Rajanayagam, Odelia; Semple, Robert; Luan, Jian'an; Bath, Louise; Zalin, Anthony; Labib, Mourad; Kumar, Sudhesh; Simpson, Helen; Blom, Dirk; Marais, David; Schwabe, John; Barroso, Inês; Trembath, Richard; Wareham, Nicholas; Nagy, Laszlo; Gurnell, Mark; O'Rahilly, Stephen; Chatterjee, Krishna.

Affiliation

Agostini M; Department of Medicine, University of Cambridge, United Kingdom.

Cell Metab ; 4(4): 303-11, 2006 Oct.

Article in En | MEDLINE | ID: mdl-17011503

Subject(s)

DNA/metabolism; Insulin Resistance/genetics; Lipodystrophy/genetics; Lipodystrophy/metabolism; PPAR gamma/genetics; DNA, Complementary/genetics; Gene Expression Profiling; Humans; Mutation; PPAR gamma/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Insulin Resistance / PPAR gamma / Lipodystrophy Limits: Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2006 Type: Article Affiliation country: United kingdom

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