Cu(II) potentiation of Alzheimer Abeta1-40 cytotoxicity and transition on its secondary structure.

Dai, Xue-Ling; Sun, Ya-Xuan; Jiang, Zhao-Feng

Dai, Xue-Ling; Sun, Ya-Xuan; Jiang, Zhao-Feng.

Affiliation

Dai XL; College of Life Science, Capital Normal University, Beijing 100037, China.

Acta Biochim Biophys Sin (Shanghai) ; 38(11): 765-72, 2006 Nov.

Article in En | MEDLINE | ID: mdl-17091193

Subject(s)

Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Copper/metabolism; Peptide Fragments/metabolism; Amyloid beta-Peptides/chemistry; Animals; Animals, Newborn; Cations, Divalent; Cell Survival/drug effects; Cells, Cultured; Circular Dichroism; Copper/chemistry; Copper/toxicity; Electron Spin Resonance Spectroscopy; Hydrogen Peroxide/chemistry; Neurons/drug effects; Neurons/metabolism; Peptide Fragments/chemistry; Potassium Iodide/chemistry; Protein Structure, Secondary; Rats; Rats, Sprague-Dawley; Spectrophotometry; Xanthine/chemistry; Xanthine Oxidase/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Amyloid beta-Peptides / Copper / Alzheimer Disease Limits: Animals Language: En Journal: Acta Biochim Biophys Sin (Shanghai) Journal subject: BIOFISICA / BIOQUIMICA Year: 2006 Type: Article Affiliation country: China

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