Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.

Harty, T Patrick; Dib-Hajj, Sulayman D; Tyrrell, Lynda; Blackman, Rachael; Hisama, Fuki M; Rose, John B; Waxman, Stephen G

Harty, T Patrick; Dib-Hajj, Sulayman D; Tyrrell, Lynda; Blackman, Rachael; Hisama, Fuki M; Rose, John B; Waxman, Stephen G.

Affiliation

Harty TP; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

J Neurosci ; 26(48): 12566-75, 2006 Nov 29.

Article in En | MEDLINE | ID: mdl-17135418

Subject(s)

Action Potentials/genetics; Erythromelalgia/genetics; Ganglia, Spinal/physiology; Mutation; Pain/genetics; Sodium Channels/genetics; Sodium Channels/metabolism; Action Potentials/physiology; Adolescent; Amino Acid Sequence; Animals; Cell Line; Erythromelalgia/metabolism; Female; Humans; Male; Molecular Sequence Data; NAV1.7 Voltage-Gated Sodium Channel; Neurons/physiology; Pain/metabolism; Rats; Rats, Sprague-Dawley; Sodium Channels/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Action Potentials / Sodium Channels / Erythromelalgia / Ganglia, Spinal / Mutation Limits: Adolescent / Animals / Female / Humans / Male Language: En Journal: J Neurosci Year: 2006 Type: Article Affiliation country: United States

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