Resolution of chiral phosphate, phosphonate, and phosphinate esters by an enantioselective enzyme library.

Nowlan, Charity; Li, Yingchun; Hermann, Johannes C; Evans, Timothy; Carpenter, Joseph; Ghanem, Eman; Shoichet, Brian K; Raushel, Frank M

Nowlan, Charity; Li, Yingchun; Hermann, Johannes C; Evans, Timothy; Carpenter, Joseph; Ghanem, Eman; Shoichet, Brian K; Raushel, Frank M.

Affiliation

Nowlan C; Department of Chemistry, Texas A&M University, College Station, Texas 77842-3012, USA.

J Am Chem Soc ; 128(49): 15892-902, 2006 Dec 13.

Article in En | MEDLINE | ID: mdl-17147402

Subject(s)

Bacterial Proteins; Esters/chemistry; Organophosphonates/chemistry; Phosphates/chemistry; Phosphoric Triester Hydrolases; Amino Acid Substitution; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Binding Sites; Catalysis; Computer-Aided Design; Hydrolysis; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Phosphoric Triester Hydrolases/chemistry; Phosphoric Triester Hydrolases/genetics; Phosphoric Triester Hydrolases/metabolism; Stereoisomerism; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphates / Bacterial Proteins / Phosphoric Triester Hydrolases / Esters / Organophosphonates Type of study: Prognostic_studies Language: En Journal: J Am Chem Soc Year: 2006 Type: Article Affiliation country: United States

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