Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.

Hodous, Brian L; Geuns-Meyer, Stephanie D; Hughes, Paul E; Albrecht, Brian K; Bellon, Steve; Bready, James; Caenepeel, Sean; Cee, Victor J; Chaffee, Stuart C; Coxon, Angela; Emery, Maurice; Fretland, Jenne; Gallant, Paul; Gu, Yan; Hoffman, Doug; Johnson, Rebecca E; Kendall, Richard; Kim, Joseph L; Long, Alexander M; Morrison, Michael; Olivieri, Philip R; Patel, Vinod F; Polverino, Anthony; Rose, Paul; Tempest, Paul; Wang, Ling; Whittington, Douglas A; Zhao, Huilin

Hodous, Brian L; Geuns-Meyer, Stephanie D; Hughes, Paul E; Albrecht, Brian K; Bellon, Steve; Bready, James; Caenepeel, Sean; Cee, Victor J; Chaffee, Stuart C; Coxon, Angela; Emery, Maurice; Fretland, Jenne; Gallant, Paul; Gu, Yan; Hoffman, Doug; Johnson, Rebecca E; Kendall, Richard; Kim, Joseph L; Long, Alexander M; Morrison, Michael; Olivieri, Philip R; Patel, Vinod F; Polverino, Anthony; Rose, Paul; Tempest, Paul; Wang, Ling; Whittington, Douglas A; Zhao, Huilin.

Affiliation

Hodous BL; Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139-1581, USA. bhodous@amgen.com

J Med Chem ; 50(4): 611-26, 2007 Feb 22.

Article in En | MEDLINE | ID: mdl-17253678

Subject(s)

Angiogenesis Inhibitors/chemical synthesis; Benzamides/chemical synthesis; Pyridines/chemical synthesis; Receptor, TIE-2/antagonists & inhibitors; Triazines/chemical synthesis; Administration, Oral; Angiogenesis Inhibitors/pharmacokinetics; Angiogenesis Inhibitors/pharmacology; Animals; Benzamides/pharmacokinetics; Benzamides/pharmacology; Binding Sites; Blood Proteins/metabolism; Crystallography, X-Ray; Female; Humans; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Models, Molecular; Molecular Structure; Phosphorylation; Protein Binding; Pyridines/pharmacokinetics; Pyridines/pharmacology; Rats; Rats, Sprague-Dawley; Receptor, TIE-2/chemistry; Receptor, TIE-2/metabolism; Structure-Activity Relationship; Triazines/pharmacokinetics; Triazines/pharmacology; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Triazines / Benzamides / Angiogenesis Inhibitors / Receptor, TIE-2 Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: United States

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