Synthesis and in vitro evaluation of targeted tetracycline derivatives: effects on inhibition of matrix metalloproteinases.

Vidal, Aurélien; Sabatini, Massimo; Rolland-Valognes, Gaëlle; Renard, Pierre; Madelmont, Jean-Claude; Mounetou, Emmanuelle

Vidal, Aurélien; Sabatini, Massimo; Rolland-Valognes, Gaëlle; Renard, Pierre; Madelmont, Jean-Claude; Mounetou, Emmanuelle.

Affiliation

Vidal A; INSERM 484, Clermont-Ferrand F-63500, France. vidal@inserm484.u-clermont1.fr

Bioorg Med Chem ; 15(6): 2368-74, 2007 Mar 15.

Article in En | MEDLINE | ID: mdl-17267227

Subject(s)

Matrix Metalloproteinase Inhibitors; Protease Inhibitors/pharmacology; Tetracyclines/chemical synthesis; Animals; Cartilage, Articular/drug effects; Cartilage, Articular/enzymology; Chondrosarcoma/drug therapy; Chondrosarcoma/enzymology; Chondrosarcoma/pathology; Collagen/drug effects; Collagen/metabolism; Humans; In Vitro Techniques; Matrix Metalloproteinases/metabolism; Protease Inhibitors/chemical synthesis; Protease Inhibitors/chemistry; Proteoglycans/drug effects; Proteoglycans/metabolism; Rabbits; Tetracyclines/chemistry; Tetracyclines/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Tetracyclines / Matrix Metalloproteinase Inhibitors Type of study: Evaluation_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Type: Article Affiliation country: France

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