Beta-catenin overexpression in the mouse brain phenocopies lithium-sensitive behaviors.

Gould, Todd D; Einat, Haim; O'Donnell, Kelley C; Picchini, Alyssa M; Schloesser, Robert J; Manji, Husseini K

Gould, Todd D; Einat, Haim; O'Donnell, Kelley C; Picchini, Alyssa M; Schloesser, Robert J; Manji, Husseini K.

Affiliation

Gould TD; Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-3711, USA.

Neuropsychopharmacology ; 32(10): 2173-83, 2007 Oct.

Article in En | MEDLINE | ID: mdl-17299510

Subject(s)

Antimanic Agents/pharmacology; Brain/drug effects; Glycogen Synthase Kinase 3/antagonists & inhibitors; Lithium/pharmacology; beta Catenin/genetics; Animals; Behavior, Animal/drug effects; Behavior, Animal/physiology; Brain/metabolism; Brain/physiopathology; Disease Models, Animal; Genetic Predisposition to Disease/genetics; Glycogen Synthase Kinase 3/metabolism; Glycogen Synthase Kinase 3 beta; Mice; Mice, Transgenic; Mood Disorders/drug therapy; Mood Disorders/metabolism; Mood Disorders/physiopathology; Phenotype; Psychomotor Agitation/drug therapy; Psychomotor Agitation/genetics; Psychomotor Agitation/physiopathology; Up-Regulation/drug effects; Up-Regulation/physiology; beta Catenin/biosynthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Brain / Antimanic Agents / Glycogen Synthase Kinase 3 / Beta Catenin / Lithium Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Neuropsychopharmacology Journal subject: NEUROLOGIA / PSICOFARMACOLOGIA Year: 2007 Type: Article Affiliation country: United States

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