Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha.

Yan, Ling; Bulgar, Alina; Miao, Yanling; Mahajan, Varun; Donze, Jon R; Gerson, Stanton L; Liu, Lili

Yan, Ling; Bulgar, Alina; Miao, Yanling; Mahajan, Varun; Donze, Jon R; Gerson, Stanton L; Liu, Lili.

Affiliation

Yan L; Department of Medicine, Division of Hematology/Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA.

Clin Cancer Res ; 13(5): 1532-9, 2007 Mar 01.

Article in En | MEDLINE | ID: mdl-17332299

Subject(s)

Antigens, Neoplasm/drug effects; Antineoplastic Agents, Alkylating/pharmacology; DNA Repair/drug effects; DNA Topoisomerases, Type II/drug effects; DNA-Binding Proteins/drug effects; DNA/drug effects; Dacarbazine/analogs & derivatives; Hydroxylamines/pharmacology; Animals; Antigens, Neoplasm/metabolism; Apoptosis/drug effects; Blotting, Western; Bone Marrow Cells/drug effects; Bone Marrow Cells/pathology; DNA Breaks, Double-Stranded/drug effects; DNA Topoisomerases, Type II/metabolism; DNA-(Apurinic or Apyrimidinic Site) Lyase/drug effects; DNA-Binding Proteins/metabolism; Dacarbazine/pharmacology; Drug Synergism; Fluorescent Antibody Technique; Humans; Mice; Temozolomide; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: DNA / DNA Topoisomerases, Type II / Antineoplastic Agents, Alkylating / Dacarbazine / DNA-Binding Proteins / DNA Repair / Hydroxylamines / Antigens, Neoplasm Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2007 Type: Article Affiliation country: United States

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