Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides.

Chan, Chuen; Borthwick, Alan D; Brown, David; Burns-Kurtis, Cynthia L; Campbell, Matthew; Chaudry, Laiq; Chung, Chun-wa; Convery, Máire A; Hamblin, J Nicole; Johnstone, Lisa; Kelly, Henry A; Kleanthous, Savvas; Patikis, Angela; Patel, Champa; Pateman, Anthony J; Senger, Stefan; Shah, Gita P; Toomey, John R; Watson, Nigel S; Weston, Helen E; Whitworth, Caroline; Young, Robert J; Zhou, Ping

Chan, Chuen; Borthwick, Alan D; Brown, David; Burns-Kurtis, Cynthia L; Campbell, Matthew; Chaudry, Laiq; Chung, Chun-wa; Convery, Máire A; Hamblin, J Nicole; Johnstone, Lisa; Kelly, Henry A; Kleanthous, Savvas; Patikis, Angela; Patel, Champa; Pateman, Anthony J; Senger, Stefan; Shah, Gita P; Toomey, John R; Watson, Nigel S; Weston, Helen E; Whitworth, Caroline; Young, Robert J; Zhou, Ping.

Affiliation

Chan C; CVU UK Medicinal Chemistry Department, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom. chuen.8chan@gsk.com

J Med Chem ; 50(7): 1546-57, 2007 Apr 05.

Article in En | MEDLINE | ID: mdl-17338508

Subject(s)

Anticoagulants/chemical synthesis; Factor Xa Inhibitors; Factor Xa/chemistry; Morpholines/chemical synthesis; Pyrrolidines/chemical synthesis; Sulfonamides/chemical synthesis; Animals; Anticoagulants/chemistry; Anticoagulants/pharmacology; Crystallography, X-Ray; Dogs; Female; Humans; Ligands; Male; Models, Molecular; Molecular Structure; Morpholines/chemistry; Morpholines/pharmacology; Protein Binding; Prothrombin Time; Pyrrolidines/chemistry; Pyrrolidines/pharmacology; Rats; Rats, Sprague-Dawley; Serum Albumin/chemistry; Stereoisomerism; Structure-Activity Relationship; Sulfonamides/chemistry; Sulfonamides/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Sulfonamides / Factor Xa / Morpholines / Factor Xa Inhibitors / Anticoagulants Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: United kingdom

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