Suppressive effect of a novel water-soluble artemisinin derivative SM905 on T cell activation and proliferation in vitro and in vivo.

Wang, Jun-Xia; Tang, Wei; Yang, Zhong-Shun; Wan, Jin; Shi, Li-Ping; Zhang, Yu; Zhou, Ru; Ni, Jia; Hou, Li-Fei; Zhou, Yu; He, Pei-Lan; Yang, Yi-Fu; Li, Ying; Zuo, Jian-Ping

Wang, Jun-Xia; Tang, Wei; Yang, Zhong-Shun; Wan, Jin; Shi, Li-Ping; Zhang, Yu; Zhou, Ru; Ni, Jia; Hou, Li-Fei; Zhou, Yu; He, Pei-Lan; Yang, Yi-Fu; Li, Ying; Zuo, Jian-Ping.

Affiliation

Wang JX; First Department of Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.

Eur J Pharmacol ; 564(1-3): 211-8, 2007 Jun 14.

Article in En | MEDLINE | ID: mdl-17349993

Subject(s)

Artemisinins/pharmacology; Cell Proliferation/drug effects; Immunosuppressive Agents/pharmacology; T-Lymphocytes/drug effects; Animals; Artemisinins/administration & dosage; CD28 Antigens/immunology; Concanavalin A/pharmacology; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases/drug effects; Extracellular Signal-Regulated MAP Kinases/metabolism; Female; Immunosuppressive Agents/administration & dosage; Interferon-gamma/biosynthesis; Interleukin-2/biosynthesis; JNK Mitogen-Activated Protein Kinases/drug effects; JNK Mitogen-Activated Protein Kinases/metabolism; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin/immunology; Ovalbumin/pharmacology; Phosphorylation; Receptor-CD3 Complex, Antigen, T-Cell/drug effects; Receptor-CD3 Complex, Antigen, T-Cell/immunology; Spleen/cytology; Spleen/metabolism; T-Lymphocytes/metabolism; p38 Mitogen-Activated Protein Kinases/drug effects; p38 Mitogen-Activated Protein Kinases/metabolism; ras Proteins/drug effects; ras Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Artemisinins / Cell Proliferation / Immunosuppressive Agents Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2007 Type: Article

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