D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance.

Wang, Jianing; Jin, Yunho; Rapp, Kimberly L; Schinazi, Raymond F; Chu, Chung K

Wang, Jianing; Jin, Yunho; Rapp, Kimberly L; Schinazi, Raymond F; Chu, Chung K.

Affiliation

Wang J; College of Pharmacy, The University of Georgia, Athens, Georgia 30602, USA.

J Med Chem ; 50(8): 1828-39, 2007 Apr 19.

Article in En | MEDLINE | ID: mdl-17373782

Subject(s)

Anti-HIV Agents/chemical synthesis; Drug Resistance, Viral; Guanine/analogs & derivatives; HIV-1/drug effects; Nucleosides/chemical synthesis; Reverse Transcriptase Inhibitors/chemical synthesis; Anti-HIV Agents/chemistry; Anti-HIV Agents/pharmacology; Cells, Cultured; Guanine/chemical synthesis; Guanine/chemistry; Guanine/pharmacology; HIV Reverse Transcriptase/chemistry; HIV Reverse Transcriptase/genetics; HIV-1/genetics; Humans; Hydrogen Bonding; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/virology; Models, Molecular; Mutation; Nucleosides/chemistry; Nucleosides/pharmacology; Reverse Transcriptase Inhibitors/chemistry; Reverse Transcriptase Inhibitors/pharmacology; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / Reverse Transcriptase Inhibitors / Anti-HIV Agents / Drug Resistance, Viral / Guanine / Nucleosides Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: United States

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