In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs.

Radi, Marco; Adema, Auke D; Daft, Jonathan R; Cho, Jong H; Hoebe, Eveline K; Alexander, Lou-Ella M M; Peters, Godefridus J; Chu, Chung K

Radi, Marco; Adema, Auke D; Daft, Jonathan R; Cho, Jong H; Hoebe, Eveline K; Alexander, Lou-Ella M M; Peters, Godefridus J; Chu, Chung K.

Affiliation

Radi M; The University of Georgia College of Pharmacy, Athens, Georgia 30602, USA.

J Med Chem ; 50(9): 2249-53, 2007 May 03.

Article in En | MEDLINE | ID: mdl-17419604

Subject(s)

Antineoplastic Agents/chemical synthesis; Carcinoma, Non-Small-Cell Lung/drug therapy; Cytosine/analogs & derivatives; Dioxolanes/chemical synthesis; Lung Neoplasms/drug therapy; Prodrugs/chemical synthesis; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Cell Line, Tumor; Cytosine/chemical synthesis; Cytosine/chemistry; Cytosine/pharmacology; Dioxolanes/chemistry; Dioxolanes/pharmacology; Drug Screening Assays, Antitumor; Humans; Prodrugs/chemistry; Prodrugs/pharmacology; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Carcinoma, Non-Small-Cell Lung / Cytosine / Dioxolanes / Lung Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: United States

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