Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.

Shtiegman, K; Kochupurakkal, B S; Zwang, Y; Pines, G; Starr, A; Vexler, A; Citri, A; Katz, M; Lavi, S; Ben-Basat, Y; Benjamin, S; Corso, S; Gan, J; Yosef, R B; Giordano, S; Yarden, Y

Shtiegman, K; Kochupurakkal, B S; Zwang, Y; Pines, G; Starr, A; Vexler, A; Citri, A; Katz, M; Lavi, S; Ben-Basat, Y; Benjamin, S; Corso, S; Gan, J; Yosef, R B; Giordano, S; Yarden, Y.

Affiliation

Shtiegman K; Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel.

Oncogene ; 26(49): 6968-78, 2007 Oct 25.

Article in En | MEDLINE | ID: mdl-17486068

Subject(s)

ErbB Receptors/metabolism; Lung Neoplasms/metabolism; Lysosomes/metabolism; Signal Transduction/physiology; Ubiquitin/metabolism; Biotinylation; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/metabolism; Carcinoma, Non-Small-Cell Lung/pathology; Cell Line, Tumor; Dimerization; Down-Regulation; ErbB Receptors/genetics; Humans; Immunoblotting; Immunoprecipitation; Lung Neoplasms/genetics; Lung Neoplasms/pathology; Mutagenesis, Site-Directed; Mutation; Proto-Oncogene Proteins c-cbl/genetics; Proto-Oncogene Proteins c-cbl/metabolism; Receptor, ErbB-2/genetics; Receptor, ErbB-2/metabolism; STAT3 Transcription Factor; Transcription, Genetic; Ubiquitination

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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Ubiquitin / ErbB Receptors / Lung Neoplasms / Lysosomes Limits: Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2007 Type: Article Affiliation country: Israel

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