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Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).
Watterson, Scott H; Chen, Ping; Zhao, Yufen; Gu, Henry H; Dhar, T G Murali; Xiao, Zili; Ballentine, Shelley K; Shen, Zhongqi; Fleener, Catherine A; Rouleau, Katherine A; Obermeier, Mary; Yang, Zheng; McIntyre, Kim W; Shuster, David J; Witmer, Mark; Dambach, Donna; Chao, Sam; Mathur, Arvind; Chen, Bang-Chi; Barrish, Joel C; Robl, Jeffrey A; Townsend, Robert; Iwanowicz, Edwin J.
Affiliation
  • Watterson SH; Bristol-Myers Squibb Pharmaceutical Research Institute, Post Office Box 4000, Princeton, New Jersey 08543, USA. scott.watterson@bms.com
J Med Chem ; 50(15): 3730-42, 2007 Jul 26.
Article in En | MEDLINE | ID: mdl-17585753
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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Acridines / IMP Dehydrogenase Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: United States
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Acridines / IMP Dehydrogenase Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: United States