Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX.

Ghanem, Eman; Li, Yingchun; Xu, Chengfu; Raushel, Frank M

Ghanem, Eman; Li, Yingchun; Xu, Chengfu; Raushel, Frank M.

Affiliation

Ghanem E; Department of Chemistry, P.O. Box 30012, Texas A&M University, College Station, Texas 77842, USA.

Biochemistry ; 46(31): 9032-40, 2007 Aug 07.

Article in En | MEDLINE | ID: mdl-17630782

Subject(s)

Enterobacter aerogenes/enzymology; Organothiophosphorus Compounds/chemistry; Phosphoric Diester Hydrolases/chemistry; Chemical Warfare Agents/chemistry; Chemical Warfare Agents/metabolism; Cholinesterase Inhibitors/chemistry; Cholinesterase Inhibitors/metabolism; Disulfoton/chemistry; Disulfoton/metabolism; Enterobacter aerogenes/genetics; Enterobacter aerogenes/growth & development; Kinetics; Microbial Viability/drug effects; Molecular Structure; Mutation; Nitrophenols/chemistry; Nitrophenols/metabolism; Organophosphates/chemistry; Organophosphates/metabolism; Organophosphonates/chemistry; Organophosphonates/metabolism; Organothiophosphorus Compounds/metabolism; Paraoxon/chemistry; Paraoxon/metabolism; Phenols/pharmacology; Phosphoric Diester Hydrolases/biosynthesis; Phosphoric Diester Hydrolases/metabolism; Phosphoric Triester Hydrolases/chemistry; Phosphoric Triester Hydrolases/genetics; Phosphoric Triester Hydrolases/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/isolation & purification; Recombinant Proteins/metabolism; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Organothiophosphorus Compounds / Phosphoric Diester Hydrolases / Enterobacter aerogenes Language: En Journal: Biochemistry Year: 2007 Type: Article Affiliation country: United States

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