A triterpene glycoside from black cohosh that inhibits osteoclastogenesis by modulating RANKL and TNFalpha signaling pathways.

Qiu, Samuel X; Dan, Chun; Ding, Li-Sheng; Peng, Shulin; Chen, Shao-Nong; Farnsworth, Norman R; Nolta, Jan; Gross, Michael L; Zhou, Ping

Qiu, Samuel X; Dan, Chun; Ding, Li-Sheng; Peng, Shulin; Chen, Shao-Nong; Farnsworth, Norman R; Nolta, Jan; Gross, Michael L; Zhou, Ping.

Affiliation

Qiu SX; Department of Chemistry, Washington University, St. Louis, MO 63130, USA.

Chem Biol ; 14(7): 860-9, 2007 Jul.

Article in En | MEDLINE | ID: mdl-17656322

Subject(s)

Cimicifuga/chemistry; Glycosides/pharmacology; Osteoclasts/drug effects; RANK Ligand/metabolism; Signal Transduction; Triterpenes/pharmacology; Tumor Necrosis Factor-alpha/metabolism; Animals; Cell Division; Mice; Mice, Inbred C57BL; Osteoclasts/cytology

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Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Triterpenes / Signal Transduction / Tumor Necrosis Factor-alpha / Cimicifuga / RANK Ligand / Glycosides Limits: Animals Language: En Journal: Chem Biol Journal subject: BIOLOGIA / BIOQUIMICA / QUIMICA Year: 2007 Type: Article Affiliation country: United States

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