A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo.

Ji, Qun-sheng; Mulvihill, Mark J; Rosenfeld-Franklin, Maryland; Cooke, Andrew; Feng, Lixin; Mak, Gilda; O'Connor, Matthew; Yao, Yan; Pirritt, Caroline; Buck, Elizabeth; Eyzaguirre, Alexandra; Arnold, Lee D; Gibson, Neil W; Pachter, Jonathan A

Ji, Qun-sheng; Mulvihill, Mark J; Rosenfeld-Franklin, Maryland; Cooke, Andrew; Feng, Lixin; Mak, Gilda; O'Connor, Matthew; Yao, Yan; Pirritt, Caroline; Buck, Elizabeth; Eyzaguirre, Alexandra; Arnold, Lee D; Gibson, Neil W; Pachter, Jonathan A.

Affiliation

Ji QS; Oncology, OSI Pharmaceuticals, Inc., New York, New York, USA. qji@osip.com

Mol Cancer Ther ; 6(8): 2158-67, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17671083

Subject(s)

Antineoplastic Agents/pharmacology; Colorectal Neoplasms/pathology; Imidazoles/pharmacology; Protein Kinase Inhibitors/pharmacology; Pyrazines/pharmacology; Receptor, IGF Type 1/antagonists & inhibitors; Receptor, IGF Type 1/metabolism; Signal Transduction/drug effects; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacokinetics; Autocrine Communication/drug effects; Blood Glucose/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Enzyme Activation/drug effects; Female; Humans; Imidazoles/administration & dosage; Imidazoles/chemistry; Imidazoles/pharmacokinetics; Insulin-Like Growth Factor II/metabolism; Mice; Mice, Nude; Phosphorylation/drug effects; Protein Kinase Inhibitors/administration & dosage; Protein Kinase Inhibitors/chemistry; Protein Kinase Inhibitors/pharmacokinetics; Pyrazines/administration & dosage; Pyrazines/chemistry; Pyrazines/pharmacokinetics; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Colorectal Neoplasms / Signal Transduction / Receptor, IGF Type 1 / Protein Kinase Inhibitors / Imidazoles / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2007 Type: Article Affiliation country: United States

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