Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade.

Lin, Wei Yu; Gong, Qian; Seshasayee, Dhaya; Lin, Zhonghua; Ou, Qinglin; Ye, Shiming; Suto, Eric; Shu, Jean; Lee, Wyne Pun; Lee, Ching-Wei V; Fuh, Germaine; Leabman, Maya; Iyer, Suhasini; Howell, Kathy; Gelzleichter, Thomas; Beyer, Joseph; Danilenko, Dimitry; Yeh, Sherry; DeForge, Laura E; Ebens, Allen; Thompson, Jeffrey S; Ambrose, Christine; Balazs, Mercedesz; Starovasnik, Melissa A; Martin, Flavius

Lin, Wei Yu; Gong, Qian; Seshasayee, Dhaya; Lin, Zhonghua; Ou, Qinglin; Ye, Shiming; Suto, Eric; Shu, Jean; Lee, Wyne Pun; Lee, Ching-Wei V; Fuh, Germaine; Leabman, Maya; Iyer, Suhasini; Howell, Kathy; Gelzleichter, Thomas; Beyer, Joseph; Danilenko, Dimitry; Yeh, Sherry; DeForge, Laura E; Ebens, Allen; Thompson, Jeffrey S; Ambrose, Christine; Balazs, Mercedesz; Starovasnik, Melissa A; Martin, Flavius.

Affiliation

Lin WY; Department of Immunology, Genentech, South San Francisco, CA 94080, USA.

Blood ; 110(12): 3959-67, 2007 Dec 01.

Article in En | MEDLINE | ID: mdl-17687108

Subject(s)

Antibodies, Monoclonal/pharmacology; B-Cell Activation Factor Receptor/antagonists & inhibitors; Immune System Diseases/drug therapy; Immunotherapy; Lymphocyte Depletion; Neoplasms/drug therapy; Plasma Cells/immunology; Animals; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal/therapeutic use; B-Cell Activating Factor/antagonists & inhibitors; B-Cell Activating Factor/immunology; B-Cell Activation Factor Receptor/immunology; Bone Marrow Cells/immunology; Cell Survival/drug effects; Cell Survival/immunology; Immune System Diseases/immunology; Macaca fascicularis; Mice; Mice, Inbred BALB C; Neoplasms/immunology; Species Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Plasma Cells / Lymphocyte Depletion / B-Cell Activation Factor Receptor / Immune System Diseases / Immunotherapy / Antibodies, Monoclonal / Neoplasms Limits: Animals Language: En Journal: Blood Year: 2007 Type: Article Affiliation country: United States

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