Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development.

Kero, Jukka; Ahmed, Kashan; Wettschureck, Nina; Tunaru, Sorin; Wintermantel, Tim; Greiner, Erich; Schütz, Günther; Offermanns, Stefan

Kero, Jukka; Ahmed, Kashan; Wettschureck, Nina; Tunaru, Sorin; Wintermantel, Tim; Greiner, Erich; Schütz, Günther; Offermanns, Stefan.

Affiliation

Kero J; Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany.

J Clin Invest ; 117(9): 2399-407, 2007 Sep.

Article in En | MEDLINE | ID: mdl-17694176

Subject(s)

GTP-Binding Protein alpha Subunits, Gq-G11/deficiency; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism; Goiter/metabolism; Goiter/prevention & control; Thyroid Gland/metabolism; Thyroid Gland/physiopathology; Animals; Cells, Cultured; GTP-Binding Protein alpha Subunits, Gq-G11/genetics; Goiter/genetics; Goiter/pathology; Mice; Mice, Knockout; Organ Specificity; Thyrotropin/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thyroid Gland / GTP-Binding Protein alpha Subunits, Gq-G11 / Goiter Limits: Animals Language: En Journal: J Clin Invest Year: 2007 Type: Article Affiliation country: Germany

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