Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells.

Morishima, Hirotaka; Kajiwara, Keiichi; Akiyama, Kazuo; Yanagihara, Yukiyoshi

Morishima, Hirotaka; Kajiwara, Keiichi; Akiyama, Kazuo; Yanagihara, Yukiyoshi.

Affiliation

Morishima H; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara Hospital, Sagamihara, Japan.

Int Arch Allergy Immunol ; 145(2): 163-74, 2008.

Article in En | MEDLINE | ID: mdl-17851256

Subject(s)

Bronchial Hyperreactivity/physiopathology; Myocytes, Smooth Muscle/drug effects; Poly I-C/pharmacology; Receptor, Muscarinic M2/biosynthesis; Receptor, Muscarinic M3/biosynthesis; Toll-Like Receptor 3/physiology; 2-Aminopurine/pharmacology; Calcium Signaling/drug effects; Cells, Cultured/drug effects; Cells, Cultured/metabolism; Chloroquine/pharmacology; Colforsin/pharmacology; Cyclic AMP/physiology; Gene Expression Regulation/drug effects; Histamine/pharmacology; Humans; Leukotriene D4/pharmacology; Membrane Proteins/biosynthesis; Membrane Proteins/genetics; Muscarinic Antagonists/pharmacology; Myocytes, Smooth Muscle/metabolism; Receptor, Muscarinic M2/antagonists & inhibitors; Receptor, Muscarinic M2/genetics; Receptor, Muscarinic M3/antagonists & inhibitors; Receptor, Muscarinic M3/genetics; Receptors, Histamine H1/biosynthesis; Receptors, Histamine H1/genetics; Receptors, Leukotriene/biosynthesis; Receptors, Leukotriene/genetics; Signal Transduction/drug effects; eIF-2 Kinase/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Poly I-C / Bronchial Hyperreactivity / Myocytes, Smooth Muscle / Receptor, Muscarinic M2 / Receptor, Muscarinic M3 / Toll-Like Receptor 3 Limits: Humans Language: En Journal: Int Arch Allergy Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2008 Type: Article Affiliation country: Japan

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