Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology.

Berson, Amit; Knobloch, Marlen; Hanan, Mor; Diamant, Sophia; Sharoni, Michal; Schuppli, Daniel; Geyer, Brian C; Ravid, Rivka; Mor, Tsafrir S; Nitsch, Roger M; Soreq, Hermona

Berson, Amit; Knobloch, Marlen; Hanan, Mor; Diamant, Sophia; Sharoni, Michal; Schuppli, Daniel; Geyer, Brian C; Ravid, Rivka; Mor, Tsafrir S; Nitsch, Roger M; Soreq, Hermona.

Affiliation

Berson A; The Eric Roland Center for Neurodegenerative Diseases, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel.

Brain ; 131(Pt 1): 109-19, 2008 Jan.

Article in En | MEDLINE | ID: mdl-18056160

Subject(s)

Acetylcholinesterase/pharmacology; Alzheimer Disease/metabolism; Amyloid beta-Peptides/biosynthesis; Acetylcholinesterase/genetics; Acetylcholinesterase/physiology; Adult; Aged; Aged, 80 and over; Alternative Splicing; Alzheimer Disease/enzymology; Alzheimer Disease/pathology; Amyloid beta-Peptides/antagonists & inhibitors; Amyloid beta-Peptides/drug effects; Animals; Astrocytes/pathology; Brain/metabolism; Brain/pathology; Dendrites/pathology; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Hippocampus/enzymology; Humans; Male; Mice; Mice, Transgenic; Middle Aged; RNA, Messenger/genetics; Recombinant Proteins/pharmacology; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Acetylcholinesterase / Amyloid beta-Peptides / Alzheimer Disease Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Brain Year: 2008 Type: Article Affiliation country: Israel

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