A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.

Lee, Erinna F; Czabotar, Peter E; van Delft, Mark F; Michalak, Ewa M; Boyle, Michelle J; Willis, Simon N; Puthalakath, Hamsa; Bouillet, Philippe; Colman, Peter M; Huang, David C S; Fairlie, W Douglas

Lee, Erinna F; Czabotar, Peter E; van Delft, Mark F; Michalak, Ewa M; Boyle, Michelle J; Willis, Simon N; Puthalakath, Hamsa; Bouillet, Philippe; Colman, Peter M; Huang, David C S; Fairlie, W Douglas.

Affiliation

Lee EF; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

J Cell Biol ; 180(2): 341-55, 2008 Jan 28.

Article in En | MEDLINE | ID: mdl-18209102

Subject(s)

Apoptosis Regulatory Proteins/metabolism; Apoptosis; Membrane Proteins/metabolism; Neoplasm Proteins/metabolism; Peptide Fragments/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Proto-Oncogene Proteins/metabolism; Amino Acid Sequence; Animals; Apoptosis Regulatory Proteins/chemistry; Bcl-2-Like Protein 11; Cell Line, Tumor; Cells, Cultured; Humans; Ligands; Membrane Proteins/chemistry; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Sequence Data; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins/chemistry; Peptide Fragments/chemistry; Protein Binding; Proto-Oncogene Proteins/chemistry; Proto-Oncogene Proteins c-bcl-2/chemistry; Sequence Alignment; bcl-2-Associated X Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Proto-Oncogene Proteins / Apoptosis / Proto-Oncogene Proteins c-bcl-2 / Apoptosis Regulatory Proteins / Membrane Proteins / Neoplasm Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Cell Biol Year: 2008 Type: Article Affiliation country: Australia

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