A phase I clinical study of vaccination of melanoma patients with dendritic cells loaded with allogeneic apoptotic/necrotic melanoma cells. Analysis of toxicity and immune response to the vaccine and of IL-10 -1082 promoter genotype as predictor of disease progression.

von Euw, Erika M; Barrio, María M; Furman, David; Levy, Estrella M; Bianchini, Michele; Peguillet, Isabelle; Lantz, Olivier; Vellice, Alejandra; Kohan, Abraham; Chacón, Matías; Yee, Cassian; Wainstok, Rosa; Mordoh, José

von Euw, Erika M; Barrio, María M; Furman, David; Levy, Estrella M; Bianchini, Michele; Peguillet, Isabelle; Lantz, Olivier; Vellice, Alejandra; Kohan, Abraham; Chacón, Matías; Yee, Cassian; Wainstok, Rosa; Mordoh, José.

Affiliation

von Euw EM; Centro de Investigaciones Oncológicas FUCA, Cramer 1180, (1426) Buenos Aires, Argentina. evoneuw@leloir.org.ar

J Transl Med ; 6: 6, 2008 Jan 25.

Article in En | MEDLINE | ID: mdl-18221542

Subject(s)

Cancer Vaccines/toxicity; Dendritic Cells/immunology; Dendritic Cells/transplantation; Interleukin-10/genetics; Melanoma/immunology; Melanoma/pathology; Adolescent; Adult; Apoptosis; Disease Progression; Female; Genotype; Humans; Hypersensitivity, Delayed; Lymphocyte Activation; Male; Middle Aged; Necrosis; Neoplasm Staging; Patient Selection; Phagocytosis; Polymorphism, Genetic; Predictive Value of Tests; Promoter Regions, Genetic; Transplantation, Autologous

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Interleukin-10 / Cancer Vaccines / Melanoma Type of study: Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: J Transl Med Year: 2008 Type: Article Affiliation country: Argentina

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