Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

Debonis, Salvatore; Skoufias, Dimitrios A; Indorato, Rose-Laure; Liger, François; Marquet, Bernard; Laggner, Christian; Joseph, Benoît; Kozielski, Frank

Debonis, Salvatore; Skoufias, Dimitrios A; Indorato, Rose-Laure; Liger, François; Marquet, Bernard; Laggner, Christian; Joseph, Benoît; Kozielski, Frank.

Affiliation

Debonis S; Institut de Biologie Structurale, 41, rue Jules Horowitz, 38027 Grenoble Cedex 01, France.

J Med Chem ; 51(5): 1115-25, 2008 Mar 13.

Article in En | MEDLINE | ID: mdl-18266314

Subject(s)

Antineoplastic Agents/chemical synthesis; Cysteine/analogs & derivatives; Kinesins/antagonists & inhibitors; Mitosis; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Cysteine/chemical synthesis; Cysteine/chemistry; Cysteine/pharmacology; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Protein Binding

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Kinesins / Cysteine / Mitosis / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2008 Type: Article Affiliation country: France

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