Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis.

Fang, Kwang-Ming; Lee, An-Sheng; Su, Ming-Jai; Lin, Chien-Liang; Chien, Chung-Liang; Wu, Mei-Lin

Fang, Kwang-Ming; Lee, An-Sheng; Su, Ming-Jai; Lin, Chien-Liang; Chien, Chung-Liang; Wu, Mei-Lin.

Affiliation

Fang KM; Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Cardiovasc Res ; 78(3): 533-45, 2008 Jun 01.

Article in En | MEDLINE | ID: mdl-18267958

Subject(s)

Apoptosis; Calcium/metabolism; Fatty Acids, Nonesterified/metabolism; Ionophores/metabolism; Mitochondria, Heart/metabolism; Myocytes, Cardiac/metabolism; Sodium/metabolism; Animals; Animals, Newborn; Arachidonic Acid/metabolism; Caspase 3/metabolism; Cytochromes c/metabolism; Cytosol/metabolism; Female; Guinea Pigs; In Vitro Techniques; Linoleic Acid/metabolism; Male; Membrane Potentials; Microscopy, Confocal; Microscopy, Electron; Mitochondria, Heart/enzymology; Mitochondria, Heart/ultrastructure; Mitochondrial Membrane Transport Proteins/metabolism; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Myocytes, Cardiac/enzymology; Myocytes, Cardiac/ultrastructure; Oleic Acid/metabolism; Palmitic Acid/metabolism; Patch-Clamp Techniques; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sodium / Calcium / Apoptosis / Myocytes, Cardiac / Fatty Acids, Nonesterified / Ionophores / Mitochondria, Heart Limits: Animals Language: En Journal: Cardiovasc Res Year: 2008 Type: Article Affiliation country: Taiwan

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