Orally delivered foot-and-mouth disease virus capsid protomer vaccine displayed on T4 bacteriophage surface: 100% protection from potency challenge in mice.

Ren, Z J; Tian, C J; Zhu, Q S; Zhao, M Y; Xin, A G; Nie, W X; Ling, S R; Zhu, M W; Wu, J Y; Lan, H Y; Cao, Y C; Bi, Y Z

Ren, Z J; Tian, C J; Zhu, Q S; Zhao, M Y; Xin, A G; Nie, W X; Ling, S R; Zhu, M W; Wu, J Y; Lan, H Y; Cao, Y C; Bi, Y Z.

Affiliation

Ren ZJ; Expression BioSciences Inc., Somerset, NJ 08873, USA. renzhaojun@yahoo.com

Vaccine ; 26(11): 1471-81, 2008 Mar 10.

Article in En | MEDLINE | ID: mdl-18289743

Subject(s)

Bacteriophage T4/immunology; Capsid/immunology; Foot-and-Mouth Disease Virus/immunology; Foot-and-Mouth Disease/prevention & control; Viral Vaccines/immunology; Animals; Animals, Newborn; DNA, Viral/biosynthesis; DNA, Viral/genetics; DNA, Viral/immunology; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Escherichia coli/ultrastructure; Escherichia coli/virology; Foot-and-Mouth Disease/immunology; Foot-and-Mouth Disease/virology; Foot-and-Mouth Disease Virus/genetics; Foot-and-Mouth Disease Virus/pathogenicity; Injections, Subcutaneous; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron; Peptide Library; Promoter Regions, Genetic/genetics; Protein Engineering; Serotyping; Swine; Vaccines, Synthetic/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Vaccines / Capsid / Bacteriophage T4 / Foot-and-Mouth Disease Virus / Foot-and-Mouth Disease Limits: Animals Language: En Journal: Vaccine Year: 2008 Type: Article Affiliation country: United States

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