Low endogenous G-protein-coupled receptor kinase 2 sensitizes the immature brain to hypoxia-ischemia-induced gray and white matter damage.

Nijboer, Cora H A; Kavelaars, Annemieke; Vroon, Anne; Groenendaal, Floris; van Bel, Frank; Heijnen, Cobi J

Nijboer, Cora H A; Kavelaars, Annemieke; Vroon, Anne; Groenendaal, Floris; van Bel, Frank; Heijnen, Cobi J.

Affiliation

Nijboer CH; Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.

J Neurosci ; 28(13): 3324-32, 2008 Mar 26.

Article in En | MEDLINE | ID: mdl-18367599

Subject(s)

Brain Injuries/pathology; G-Protein-Coupled Receptor Kinase 2/metabolism; Gene Expression Regulation, Developmental/physiology; Neuroglia/metabolism; Neurons/metabolism; Animals; Animals, Newborn; Antigens, CD/metabolism; Antigens, Differentiation, Myelomonocytic/metabolism; Apoptosis; Brain Injuries/etiology; G-Protein-Coupled Receptor Kinase 2/deficiency; Gene Expression Regulation, Developmental/drug effects; Glutamic Acid/toxicity; Hypoxia-Ischemia, Brain/complications; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Basic Protein/metabolism; Neuroglia/drug effects; Neurons/drug effects; Neutrophil Infiltration/physiology; Peroxidase/metabolism; Regional Blood Flow/physiology; Subcellular Fractions/metabolism; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Injuries / Neuroglia / Gene Expression Regulation, Developmental / G-Protein-Coupled Receptor Kinase 2 / Neurons Type of study: Etiology_studies Limits: Animals Language: En Journal: J Neurosci Year: 2008 Type: Article Affiliation country: Netherlands

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