A blocking anti-CD28-specific antibody induces long-term heart allograft survival by suppression of the PKC theta-JNK signal pathway.

Jang, Mei-Shiang; Pan, Fan; Erickson, Laurie M; Fisniku, Ogert; Crews, Gladys; Wynn, Carmen; Hong, In Chul; Tamura, Kouichi; Kobayashi, Masakazu; Jiang, Hongsi

Jang, Mei-Shiang; Pan, Fan; Erickson, Laurie M; Fisniku, Ogert; Crews, Gladys; Wynn, Carmen; Hong, In Chul; Tamura, Kouichi; Kobayashi, Masakazu; Jiang, Hongsi.

Affiliation

Jang MS; Astellas Research Institute of America, Skokie, IL 60077, USA.

Transplantation ; 85(7): 1051-5, 2008 Apr 15.

Article in En | MEDLINE | ID: mdl-18408588

Subject(s)

CD28 Antigens/immunology; Graft Survival/immunology; Heart Transplantation/immunology; Isoenzymes/antagonists & inhibitors; MAP Kinase Kinase 4/antagonists & inhibitors; Protein Kinase C/antagonists & inhibitors; Animals; Antibody Specificity; Lymphocyte Activation; Protein Kinase C-theta; Rats; Rats, Inbred BN; Rats, Inbred Lew; Signal Transduction; T-Lymphocytes/immunology; Transplantation, Homologous/immunology; Transplantation, Isogeneic/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase C / Heart Transplantation / CD28 Antigens / MAP Kinase Kinase 4 / Graft Survival / Isoenzymes Limits: Animals Language: En Journal: Transplantation Year: 2008 Type: Article Affiliation country: United States

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