Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.

Pino, Steven C; O'Sullivan-Murphy, Bryan; Lidstone, Erich A; Thornley, Thomas B; Jurczyk, Agata; Urano, Fumihiko; Greiner, Dale L; Mordes, John P; Rossini, Aldo A; Bortell, Rita

Pino, Steven C; O'Sullivan-Murphy, Bryan; Lidstone, Erich A; Thornley, Thomas B; Jurczyk, Agata; Urano, Fumihiko; Greiner, Dale L; Mordes, John P; Rossini, Aldo A; Bortell, Rita.

Affiliation

Pino SC; Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Cell Stress Chaperones ; 13(4): 421-34, 2008 Dec.

Article in En | MEDLINE | ID: mdl-18418732

Subject(s)

Endoplasmic Reticulum/enzymology; Lymphocyte Activation/immunology; Protein Kinase C/metabolism; Signal Transduction; Stress, Physiological; T-Lymphocytes/enzymology; T-Lymphocytes/immunology; Animals; Endoplasmic Reticulum/drug effects; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation/drug effects; Heat-Shock Proteins/metabolism; Immune Tolerance/drug effects; Interleukin-2/biosynthesis; Ionomycin/pharmacology; Lymphocyte Activation/drug effects; Male; Mice; Models, Biological; Molecular Chaperones/metabolism; Phorbol 12,13-Dibutyrate/pharmacology; Protein Kinase C/antagonists & inhibitors; Protein Kinase Inhibitors/pharmacology; Receptors, Antigen, T-Cell/metabolism; Signal Transduction/drug effects; Stress, Physiological/drug effects; T-Lymphocytes/cytology; T-Lymphocytes/drug effects; Thapsigargin/pharmacology; Up-Regulation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Physiological / Protein Kinase C / Lymphocyte Activation / T-Lymphocytes / Signal Transduction / Endoplasmic Reticulum Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Stress Chaperones Year: 2008 Type: Article Affiliation country: United States

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