Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib.

Bocci, G; Falcone, A; Fioravanti, A; Orlandi, P; Di Paolo, A; Fanelli, G; Viacava, P; Naccarato, A G; Kerbel, R S; Danesi, R; Del Tacca, M; Allegrini, G

Bocci, G; Falcone, A; Fioravanti, A; Orlandi, P; Di Paolo, A; Fanelli, G; Viacava, P; Naccarato, A G; Kerbel, R S; Danesi, R; Del Tacca, M; Allegrini, G.

Affiliation

Bocci G; Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy. g.bocci@med.unipi.it

Br J Cancer ; 98(10): 1619-29, 2008 May 20.

Article in En | MEDLINE | ID: mdl-18443598

Subject(s)

Angiogenesis Inhibitors/pharmacology; Antineoplastic Agents, Phytogenic/pharmacology; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Camptothecin/analogs & derivatives; Colorectal Neoplasms/blood supply; Colorectal Neoplasms/drug therapy; Indoles/pharmacology; Pyrroles/pharmacology; Angiogenesis Inhibitors/administration & dosage; Animals; Antineoplastic Agents, Phytogenic/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Apoptosis/drug effects; Camptothecin/administration & dosage; Camptothecin/pharmacology; Cell Proliferation/drug effects; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic/drug effects; HT29 Cells; Humans; Immunoenzyme Techniques; Immunohistochemistry; Indoles/administration & dosage; Irinotecan; Male; Mice; Mice, Nude; Microcirculation/drug effects; Pyrroles/administration & dosage; Thrombospondin 1/drug effects; Thrombospondin 1/metabolism; Transplantation, Heterologous; Vascular Endothelial Growth Factor A/drug effects; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Camptothecin / Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Angiogenesis Inhibitors / Indoles / Antineoplastic Agents, Phytogenic Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Br J Cancer Year: 2008 Type: Article Affiliation country: Italy

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