Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination.

Li, Jiadong; Ghiani, Cristina A; Kim, Jin Young; Liu, Aixiao; Sandoval, Juan; DeVellis, Jean; Casaccia-Bonnefil, Patrizia

Li, Jiadong; Ghiani, Cristina A; Kim, Jin Young; Liu, Aixiao; Sandoval, Juan; DeVellis, Jean; Casaccia-Bonnefil, Patrizia.

Affiliation

Li J; Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

J Neurosci ; 28(24): 6118-27, 2008 Jun 11.

Article in En | MEDLINE | ID: mdl-18550754

Subject(s)

Demyelinating Diseases/pathology; Oligodendroglia/pathology; Transcription, Genetic/physiology; Tumor Suppressor Protein p53/metabolism; Animals; Benzothiazoles/pharmacology; Cells, Cultured; Cuprizone; Demyelinating Diseases/chemically induced; Demyelinating Diseases/genetics; Disease Models, Animal; Enzyme Inhibitors/pharmacology; Lateral Ventricles/cytology; Lateral Ventricles/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia/drug effects; Microglia/metabolism; Oligodendroglia/drug effects; Oligonucleotide Array Sequence Analysis/methods; Toluene/analogs & derivatives; Toluene/pharmacology; Transcription, Genetic/drug effects; Tumor Suppressor Protein p53/deficiency

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Oligodendroglia / Tumor Suppressor Protein p53 / Demyelinating Diseases Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Year: 2008 Type: Article Affiliation country: United States

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