Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta.

Liu, Yongsheng; Wu, Jiangyue; Weissig, Helge; Betancort, Juan M; Gai, Wen Zhi; Leventhal, Phillip S; Patricelli, Matthew P; Samii, Babak; Szardenings, Anna K; Shreder, Kevin R; Kozarich, John W

Liu, Yongsheng; Wu, Jiangyue; Weissig, Helge; Betancort, Juan M; Gai, Wen Zhi; Leventhal, Phillip S; Patricelli, Matthew P; Samii, Babak; Szardenings, Anna K; Shreder, Kevin R; Kozarich, John W.

Affiliation

Liu Y; ActivX Biosciences, 11025 N. Torrey Pines Road, La Jolla, CA 92037, USA.

Bioorg Med Chem Lett ; 18(22): 5955-8, 2008 Nov 15.

Article in En | MEDLINE | ID: mdl-18774710

Subject(s)

Fluorescent Dyes/chemical synthesis; Fluorescent Dyes/pharmacology; Indoles/chemical synthesis; Indoles/pharmacology; Maleimides/chemical synthesis; Maleimides/pharmacology; Protein Kinase C-alpha/metabolism; Protein Kinase C/metabolism; Catalytic Domain; Drug Design; Fluorescent Dyes/chemistry; Humans; Indoles/chemistry; Jurkat Cells; Maleimides/chemistry; Molecular Structure; Protein Kinase C beta; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase C / Protein Kinase C-alpha / Fluorescent Dyes / Indoles / Maleimides Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: United States

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